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oncology --- urological oncological diseases --- cancer biomarkers --- cancer therapy --- molecular tumor pathology --- tumor microenvironment --- Oncology --- Carcinogenesis --- Oncology. --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Molecular carcinogenesis --- Pathology, Molecular --- Tumors --- Molecular aspects --- Molecular aspects. --- Pathogenesis

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Lung cancer is the leading cause of mortality worldwide, with a low survival rate. Carcinogenesis generally requires a constellation of entwined steps, involving both innate cellular and environmental factors. This book shares the updated knowledge on the origin and development of cancer through genotypic changes which upset the physiological balance between cell proliferation, differentiation, growth control, and apoptosis. The emphasis is put on the role of microRNA proteins involved in the cellular processes above outlined. Cognitive changes, related to dysregulated cellular mechanisms in cancer cells, as yet unchartered area of research, also are tackled. A better understanding of the molecular and cellular biology of lung cancer is the key source of breakthroughs in the diagnosis and prognosis, and finding more effective therapies that target specific mutations. The book provides a source of current facts and trends in clinical research and practice. It will be of interest to clinicians, researchers, and other medical professionals. .

Medicine. --- Cancer research. --- Respiratory organs --- Cell biology. --- Biomedicine. --- Cancer Research. --- Pneumology/Respiratory System. --- Cell Biology. --- Diseases. --- Carcinogenesis --- Cancer. --- Molecular aspects. --- Molecular carcinogenesis --- Pathology, Molecular --- Oncology. --- Pneumology. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Respiratory organs—Diseases. --- Cancer research --- Respiratory Tract Neoplasms. --- Respiratory Neoplasms --- Respiratory System Neoplasms --- Neoplasm, Respiratory --- Neoplasm, Respiratory System --- Neoplasm, Respiratory Tract --- Respiratory Neoplasm --- Respiratory System Neoplasm --- Respiratory Tract Neoplasm

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Focuses on molecular aspects of the mechanisms involved in chemical, physical, and viral (biological) carcinogenesis. Areas of interest include, but are not limited to, the structure, expression, or function of genes or gene products associated with normal growth and differentiation and alterations in neoplasia; characterization of genes or gene products expressed in preneoplastic or neoplastic cells; molecular studies that define a specific function of a tumor-associated protein or its effects on cellular function; virtually all research on molecular aspects of oncogenes, tumor suppressor genes, and their gene products; carcinogenesis studies in transgenic mice; and research on human tumor viruses.

Carcinogenesis --- Cancérogenèse --- Molecular aspects --- Aspect moléculaire --- Périodiques. --- Molecular aspects. --- Molecular carcinogenesis --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathogenesis --- Pathology, Molecular --- Pathology --- Genetic toxicology --- Carcinogens --- Molecular Biology --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- Carcinogen --- Oncogen --- Oncogens --- Tumor Initiator --- Tumor Initiators --- Tumor Promoter --- Tumor Promoters --- Initiator, Tumor --- Initiators, Tumor --- Promoter, Tumor --- Promoters, Tumor --- Benzidines --- Carcinogens. --- Cancérogènes. --- Periodicals. --- Cancer causing agents --- Carcinogenic agents --- Hazardous substances

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Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research.

Medicine. --- Cancer research. --- Gene expression. --- Molecular biology. --- Oncology. --- Cytokines. --- Growth factors. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Cytokines and Growth Factors. --- Gene Expression. --- Carcinogenesis --- Molecular aspects. --- Molecular carcinogenesis --- Pathology, Molecular --- Oncology  . --- Genes --- Genetic regulation --- Cellular immunity --- Immune response --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Expression --- Regulation --- Health Workforce --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.

Cancer. --- Cancer cells. --- Carcinogenesis. --- Carcinogenesis - Molecular aspects. --- Carcinogens. --- Gene Expression Regulation, Neoplastic. --- Genomic Instability. --- Neoplasms. --- Carcinogenesis --- Cancer cells --- Cancer --- Gene Expression Regulation, Neoplastic --- Genomic Instability --- Carcinogens --- Genetics --- Neoplasms --- Gene Expression Regulation --- Diseases --- Noxae --- Biology --- Pathologic Processes --- Genetic Phenomena --- Mutation --- Genetic Processes --- Pathological Conditions, Signs and Symptoms --- Genetic Variation --- Phenomena and Processes --- Biological Science Disciplines --- Toxic Actions --- Chemical Actions and Uses --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Molecular aspects --- Pathophysiology --- Genetic aspects --- Molecular aspects. --- Pathophysiology. --- Genetic aspects. --- Cancer genetics --- Molecular carcinogenesis --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Cancer genes --- Cells --- Pathology, Cellular --- Pathology, Molecular --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Biomedicine, general. --- Cancer research --- Cancer Biology. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors